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KMID : 0032220230350060432
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Annals of Dermatology
2023 Volume.35 No. 6 p.432 ~ p.438
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Clinical Characteristics of Lichen Amyloidosis Associated with Atopic Dermatitis: A Single Center, Retrospective Study
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Oh Seung-Min
Ahn Hye-Jin
Shin Min-Kyung
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Abstract
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Background: Lichen amyloidosis is a chronic pruritic skin disorder associated with atopic dermatitis, however, the pathogenetic link between these two conditions remains to be elu- cidated. Only limited research has been performed on patients diagnosed with both pruritic dermatological conditions.
Objective: This study aimed to analyze the clinical features of lichen amyloidosis associated with atopic dermatitis.
Methods: We conducted a matched case-control study of incident lichen amyloidosis with atopic dermatitis between March 2020 and February 2022. Among the 2,481 patients with atopic dermatitis, 20 patients diagnosed with lichen amyloidosis and atopic dermatitis were included as case patients, and 20 patients diagnosed with atopic dermatitis were enrolled as controls. The controls were matched to cases (1:1) by age and sex. We retrospectively re- viewed the medical records of the patients.
Results: The prevalence of lichen amyloidosis associated with atopic dermatitis was approxi- mately 0.8%, with a male:female sex ratio of 2.33:1. The recorded onset of lichen amyloidosis associated with atopic dermatitis was more common in adult patients, with moderate-to- severe atopic dermatitis. Lichen amyloidosis lesions in patients with atopic dermatitis were most commonly found on the extremities, sparing the head and neck region. The presence of lichen amyloidosis had no significant impact on severity of atopic dermatitis.
Conclusion: In patients with lichen amyloidosis associated with atopic dermatitis, the clini- cal manifestations of lesions are similar to those of conventional lichen amyloidosis lesions in terms of morphology and regional distribution. Further research is required to elucidate the link between the pathogenesis of these two pruritic dermatological conditions.
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KEYWORD
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Atopic dermatitis, Lichen amyloidosis, Pruritus
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